🦠 Myth about Bacteriostatic and Bacteriocidal
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🦠Bacteriostatics don’t kill bacteria ?
Defining bactericidal and bacteriostatic Two definitions are important to clarify here.
First, the minimum inhibitory concentration (MIC) is defined as the concentration that inhibits visible bacterial growth at 24 hours of growth in specific media, at a specific temperature, and at a specific carbon dioxide concentration.
Second, the minimum bactericidal concentration (MBC) is the concentration of a drug that results in a 1,000-fold reduction in bacterial density at 24 hours of growth in the same specific conditions.
The formal definition of a bactericidal antibiotic is one for which the ratio of MBC to MIC is ≤ 4, while a bacteriostatic agent has an MBC to MIC ratio of > 4.
Thus, an antibiotic that achieves a >1,000-fold reduction in bacterial density but does so at a concentration that is 8-fold above the MIC of the drug is considered bacteriostatic, despite the fact that it clearly kills the bacteria. Similarly, an antibiotic that achieves a 10-fold, or even a 500-fold, reduction in bacterial density at a concentration of 2- to 4-fold above the MIC is characterized as bacteriostatic, even though it demonstrates impressive killing ability.
All antibiotics that are considered bacteriostatic do kill bacteria in vitro, just at concentrations that are farther above their MICs than bactericidal agents
All antibacterial kill bacterias at certain concentration in specified set conditions.
Bacteriocidal : MIC : MBC <4
Bacteriostatic: MIC : MBC >4
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